In 2021, galcanezumab, erenumab, and fremanezumab were approved for migraine in Japan, making them the first approved treatments in Japan to inhibit the calcitonin gene-related peptide (CGRP) or block its receptor. Koichi Hirata, MD, Dokkyo Medical University, Sōka, Japan, discusses how this approval has impacted migraine treatment in Japan. Additionally, Dr Hirata talks about a long-term open-label safety study of galcanezumab in Japanese patients with migraine. This interview took place during the International Headache Congress 2021.