Previous studies support the key role of the pons during the pain phase of the migraine. Roberta Messina, MD, Vita-Salute San Raffaele University, Milan, Italy, talks on a cross-sectional, longitudinal study investigating resting state functional connectivity (RSFC) changes of the pons in migraine patients. The study aimed to map RSFC changes of the pons in migraine patients for 4 years and explore the association between those abnormalities and the characteristics of the patients. Imaging findings indicated that compared to controls, at baseline, migraine patients showed increased RSFC between the pons, the cerebellum, and the temporal and lingual gyros. After 4 years, migraine patients showed decreased RSFC between the pons and the precuneus compared to controls. Additionally, compared to controls, migraine patients developed both decreased and increased RSFC between the pons and the cerebellum, suggesting that distinct adaptive responses might occur over time in the cerebellum. RSFC changes between the left pons and ipsilateral cerebellar crus I might represent a maladaptive response contributing to migraine worsening. This interview took place during the European Academy of Neurology 2021 congress.
Roberta Messina received speakers honoraria from Novartis, Eli Lilly and Teva Pharmaceutical Industries.