Sofia Reimão, MD, University of Lisbon, Lisbon, Portugal, discusses the utility of multimodal MRI for the diagnosis and differential diagnosis of Parkinson’s disease (PD). The establishment of objective, reliable imaging biomarkers in PD has revolutionized the in vivo study of the brain and thus, MRI studies are becoming increasingly relevant in the setting of PD. Combining various MRI parameters can amplify the diagnostic potential of MRI and provide more information from a single scan. Assessment of PD is currently based on clinical symptoms that make an accurate diagnosis challenging and there is no reliable method to accurately diagnose PD in its pre-motor stages. Given the time delay between the start of neurodegeneration and the onset of motor symptoms, developing methods for early PD detection is of critical importance. Multimodal imaging has the potential to aid diagnosis in early or premanifest stages, and to track pathological changes throughout disease. This interview took place during the 2021 International Congress of Parkinson’s Disease and Movement Disorders.