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AAN 2022 | Mechanisms and triggers of autoimmune neurological conditions

Divyanshu Dubey, MBBS, Mayo Clinic, Rochester, MN, discusses the pathophysiological basis of autoimmune diseases of the nervous system and factors that may trigger their development. Immune-mediated disorders can be categorized into autoimmune disorders and autoinflammatory disorders. Autoimmune disorders can be antibody-mediated conditions, such as neurofascin-155 or T-cell-mediated conditions. Regarding the factors that may trigger their development, the most known triggers are underlying cancer and infections. However, some patients present with idiopathic forms where the exact cause is unknown. This interview took place at the American Academy of Neurology 2022 Congress in Seattle, WA.


Dr Dubey has consulted for UCB, Immunovant and Astellas Pharmaceuticals. All compensation for consulting activities is paid directly to Mayo Clinic. Dr Dubey has patents pending for Kelch-like protein 11 (KLHL11) IgG and Leucine Zipper 4 (LUZP4) IgG as markers of neurological autoimmunity.