Tanuja Chitnis, MD, Brigham and Women’s Hospital, Boston, MA, shares the findings of an exploration of the association between serum neurofilament light (sNfL) and health outcomes in multiple sclerosis (MS). Over 300 patient serum samples were studied alongside health-outcome measurements. The data showed baseline sNfL levels correlated with quality of life, baseline Expanded Disability Status Scale (EDSS) and steroid use. Additionally, average sNfL levels correlated with physical-role limitations, social functioning, and inpatient stays. The findings suggest sNfL is an independent biomarker that correlated with health outcomes and resource use in MS. This interview took place during the ACTRIMS Forum 2021.