Raphael Schneider, MD, PhD, FRCPC, CIP, St. Michael’s Hospital, Toronto, Canada, comments on multiple sclerosis (MS) management shifting towards treating patients with radiologically isolated syndrome (RIS). Schneider mentions the potential to identify subgroups of patients with RIS who would benefit from therapeutic intervention, based on their MRI results and biomarkers, whilst others are observed and followed before being offered therapy. This interview took place at the ACTRIMS Forum 2022 in West Palm Beach, Florida.