Michael Fox, MD, PhD, Brigham and Women’s Hospital & Harvard Medical School, Boston, MA, outlines key next steps using network mapping for the discovery and optimization of accurate deep brain stimulation (DBS) targets. Lesion network mapping has identified causal brain circuits associated with specific movement disorder symptoms, leading to the discovery of new potential targets for DBS. Dr Fox emphasizes the importance of using all available DBS data to further our understanding of these brain networks and aid optimization of stimulation sites. Additionally, these potential targets and the value of lesion/DBS network mapping for target discovery need validation. DBS reprogramming trials and prospective studies will provide crucial information. Dr Fox also discusses the potential of lesioning by focused ultrasound using the optimized DBS targets. This interview took place during the 2021 International Congress of Parkinson’s Disease and Movement Disorders.