Jeffrey A. Cohen, MD, Cleveland Clinic, Cleveland, OH, comments on exciting topics discussed during the first day of the ACTRIMS Forum 2022. Themed ‘Biomarkers in MS’, the meeting has generated lots of discussion surrounding novel biomarkers for early diagnosis, prognostication, and predicting treatment response. Dr Cohen highlights rim lesions as a key area of progress, which may be a useful marker to incorporate into MS diagnostic criteria. This interview took place at the ACTRIMS Forum 2022 in West Palm Beach, Florida.