Rhonda Voskuhl, MD, University of California, Los Angeles, CA, shares her highlights from the ACTRIMS Forum 2021. These include the Kenneth P. Johnson memorial lecture on the changing neuroinflammatory response over the clinical course of multiple sclerosis (MS), as well as talks on myelin regeneration with oligodendrocytes and oligodendrocyte precursor cells. Dr Voskuhl also notes the ‘Spectrum of MS across the Lifespan’ as an important session, appreciating the different phases of MS to allow for precision approaches. This interview took place during the ACTRIMS Forum 2021.