AES 2022 | Predicting seizures in patients with dementia

New data presented at the American Epilepsy Society (AES) 2022 meeting has demonstrated that the presence of active seizures in dementia is associated with worse clinical outcomes, higher mortality rates, and shorter lifespans. The analysis of longitudinal data from over 26,000 patients showed that patients with active seizures were at a significantly higher risk of dying at a younger age, compared to patients without active seizures (HR 1.76). Ifrah Zawar, MD, University of Virginia School of Medicine, Charlottesville, VA, comments on her planned next steps to continue this work. Dr Zawar plans to enroll patients with dementia to undergo 24-hour EEG monitoring. Comparing those with and without epileptiform activity will give insights at an earlier stage, prior to the development of clinical seizures. It is hoped that this study may identify distinguishing clinical or imaging features that could aid in the prediction of seizures in patients with dementia. This interview took place at the American Epilepsy Society (AES) Annual Meeting 2022 in Nashville, TN.

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