Significant cognitive and behavioral adverse events are often associated with antiseizure medications. William E. Rosenfeld, MD, FAAN, The Comprehensive Epilepsy Care Center for Children and Adults, St Louis, MO, discusses a pooled analysis of the Phase II double-blind C013 (NCT01397968) and C017 (NCT01866111) studies and their open-label extensions, and the C021 Phase III open-label safety study (NCT02535091), evaluating the cognitive and psychiatric treatment-related adverse events associated with cenobamate use. During the 5-year analysis period, incidence of both cognitive and psychiatric adverse events was low. In patients with a history of psychiatric events, incidence was found to be lower than at baseline. This interview took place at the American Academy of Neurology 2022 Congress in Seattle, WA.