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World Sleep 2022 | The effects of Alzheimer’s disease pathophysiology on sleep-dependent memory

Bryce Mander, PhD, University of California Irvine, Irvine, CA, discusses the effects of Alzheimer’s disease pathophysiology on sleep-dependent memory. Through emerging work over the past few years, Dr. Mander suggests that Alzheimer’s disease pathophysiology directly impacts core brain oscillations during sleep that are relevant to sleep-dependent memory. This includes the likes of amyloid plaque deposits in the cortex disrupting the expression of slow waves in the brain, hippocampal ripples, tau pathology impacting the expression of sleep spindles, the corral in the coupling between slow waves and sleep spindles – and tau pathology in the cortex on the expression of slow waves. Dr. Mander states that in many cases, these factors have been impacting sleep expression in such a way that sleep-dependent memory is impaired. This interview took place at the World Sleep Congress 2022 in Rome, Italy.