Rami Apelian, MD, MPH, FAES, Huntington Headache and Neurology, Arcadia, CA, discusses future directions in migraine prevention treatment. Moving forward, Dr Apelian is investigating new drugs targeting CGRP, utilizing different delivery mechanisms. Furthermore, there is also an incentive to investigate abortive and preventive drugs that target other aspects of the transmission system. This would provide patients with more targeted therapy, helping their individual needs. This interview took place during the 2022 American Headache Society (AHS) Meeting in Denver, CO.