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ACTRIMS 2021 | Adiponectin induces pro-inflammatory immune activation in pediatric-onset MS

Amit Bar-Or, MD, FRCPC, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, outlines the findings of an investigation into the potential pathophysiologic contribution of adipokines in pediatric-onset multiple sclerosis. Obesity is associated with an increased risk of MS and greater MS disease activity. To investigate potential biological mechanisms behind this, adiponectin (APN) levels were measured in 169 children with MS or other inflammatory demyelinating syndromes. The results showed that children with MS had higher levels of APN compared to other cohorts and healthy controls, potentially contributing to enhanced pro-inflammatory immune responses. Additionally, APN-containing serum from these patients was shown to cause activation of CD14-positive monocytes, microglia, and T-cells. This interview took place during the ACTRIMS Forum 2021.

Disclosures

Dr. Bar-Or has participated as a speaker in meetings sponsored by and received consulting fees and/or grant support from: Accure, Atara Biotherapeutics, Biogen, BMS/Celgene/Receptos, GlaxoSmithKline, Gossamer, Janssen/Actelion, Medimmune, Merck/EMD Serono, Novartis, Roche/Genentech, Sanofi-Genzyme.
Dr. Bar-Or receives research funding from the National Institutes of Health (NIH), The National MS Society (NMSS), the Juvenile Diabetes Research Foundation (JDRF), the Canadian Institutes of Health Research, Multiple Sclerosis Society of Canada, Multiple Sclerosis Scientific Foundation and Melissa and Paul Anderson Chair in Neuroinflammation.
Dr. Bar-Or serves on the: Board of Directors for Americas Committee in Treatment and Research in Multiple Sclerosis (ACTRIMS); Education Committee for the Federation of Clinical Immunology Societies (FOCIS); Steering Committee of the Immune Tolerance Network (ITN); President, International Society for Neuroimmunology (ISNI).