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EAN 2021 | Is REM sleep a motor state?

Pierre-Hervé Luppi, PhD, University of Lyon, Lyon, France, gives an overview of the latest understanding of paradoxical (REM) sleep. During REM sleep, muscle atonia is actively generated through systems which repress movement. When this inhibitory system is removed, muscle atonia is lost, as is seen in REM sleep behavior disorder (RBD). Deciphering the precise systems and neuronal networks involved in the generation and control of REM sleep is an ongoing challenge, with many questions remaining unanswered. The involvement of signaling from the cortex has been hypothesized and ongoing research is using transgenic mouse models to identify neuronal populations responsible for REM sleep control. This interview took place during the European Academy of Neurology 2021 congress.