Alfonso Fasano, MD, PhD, University of Toronto, Toronto, Canada, shares a sign-based diagnostic approach to assessing gait, balance, and posture, which uses the major presenting signs as a starting point to guide a tailored search into the underlying neurological syndrome. Dr Fasano notes the impracticalities of classic textbook approaches to diagnose gait disorders in clinical practice. Notably, in early disease stages, patients often do not display all the features that characterize a particular syndrome, but just one that can be associated with several diagnoses. By focusing on the presenting signs and considering all possible causes, these options can successively be narrowed down to an accurate final diagnosis. This interview took place during the 2021 International Congress of Parkinson’s Disease and Movement Disorders.