Augusto Miravalle, MD, FAAN, University of Colorado School of Medicine, Aurora, CO, explains the steps required to reach precision medicine in multiple sclerosis (MS), highlighting the need to validate and understand individual markers, the importance of combining various markers and better understanding how they may help in treatment decisions, and the value of using genetic biomarkers in the future. This interview took place at the American Academy of Neurology 2022 Congress in Seattle, WA.