Amynah Pradhan, PhD, University of Illinois at Chicago, Chicago, IL, provides an overview of her talk on animal modeling of headache and design implementation. With the main purpose of Dr Pradhan’s talk to share the difficulties in performing pre-clinical studies on headache, there is a great emphasis on the best practices to mitigate the variability issues. Animal models can prove challenging when replicating results – therefore, providing insight on how to replicate findings is a crucial aspect of these investigations. This interview took place during the 2022 American Headache Society (AHS) Meeting in Denver, CO.