Edward Wild, MA, MB BChir, FRCP, PhD, UCL Queen Square Institute of Neurology, London, UK, discusses recent research investigating the endo-lysosomal pathway in Huntington’s disease to highlight potential biomarkers. In the study including 80 participants of pre-manifested and manifested Huntington’s disease, none of the proteins showed systematic alteration. However, amyloid concentration was strongly associated with disease severity. Amyloid has not previously been implicated in Huntington’s and therefore indicates a potential avenue for further research. This interview was recorded during an online conference call with The Video Journal of Neurology (VJNeurology).