ECTRIMS 2022 | Genetic contributions to the IgG index in MS

The immunoglobulin gamma (IgG) index is often used to help diagnose multiple sclerosis (MS) as most MS patients have higher levels of IgG, and it is also associated with the clinical severity of MS. One way to better understand the heterogeneity of MS outcomes is to understand the genetic contributions to this index. Researchers in Germany, as part of the MultipleMS consortium, investigated the genetic variants associated with the IgG index using a genome-wide association study in 229 patients. Adil Harroud, MD, McGill University, Montreal, Canada, and his team have now replicated these previously identified genetic associations as well as identifying a novel one. Dr Harroud is currently working to find out how this novel genetic association affects the IgG index level. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress 2022 in Amsterdam, The Netherlands.

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