Dimos-Dimitrios Mitsikostas, MD, PhD, National & Kapodistrian University of Athens, Athens, Greece, gives an overview of the latest controversies in the field of headache treatment, including whether oral anti-calcitonin gene-related peptide (CGRP) medications or monoclonal antibodies are superior in the treatment of headaches. Additional contentious topics discussed include determining the optimal treatment strategy for symptomatic migraine attacks, as well as the pathogenesis of migraines. This interview was conducted during the 2022 World Congress on Controversies in Neurology (CONy) meeting.