Amynah Pradhan, PhD, University of Illinois at Chicago, Chicago, IL, shares her highlights and perspectives on the hot topics in basic science symposium at the 2022 American Headache Society (AHS) Meeting. With an increasing general interest in the hot topics in basic science at AHS over the past few years, there has been an array of speakers providing high-level, exciting research from the biology of a headache to novel screening techniques. There is much enthusiasm from basic scientists to clinicians alike, emphasizing the importance of these sessions at future AHS meetings. This interview took place during the 2022 American Headache Society (AHS) Meeting in Denver, CO.