ECTRIMS 2021 | The future of biomarkers in MS: novel discoveries and defining protocols
Charlotte Teunissen, PhD, VU University Medical Center Amsterdam, The Netherlands, discusses ongoing work in her group, looking to identify novel treatment response biomarkers for progressive multiple sclerosis (MS). Using Olink technology for multiplex protein biomarker discovery, Prof. Teunissen’s team are analyzing data from patients treated with natalizumab or ocrelizumab, hoping to discover markers that distinguish individuals with persistent progression from those with controlled disease. Prof. Teunissen also discusses work to prepare for the implementation of novel biomarkers, such as defining detailed protocols for contactin 1 and GFAP analysis. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) congress 2021.
Disclosures
Research of Prof. Teunissen is supported by the European Commission (Marie Curie International Training Network, grant agreement No 860197 (MIRIADE), and JPND), Health Holland, the Dutch Research Council (ZonMW), Alzheimer Drug Discovery Foundation, The Selfridges Group Foundation, Alzheimer Netherlands, Alzheimer Association.
Prof. Teunissen is a recipient of ABOARD, which is a public-private partnership receiving funding from ZonMW (#73305095007) and Health~Holland, Topsector Life Sciences & Health (PPP-allowance; #LSHM20106). More than 30 partners participate in ABOARD. ABOARD also receives funding from Edwin Bouw Fonds and Gieskes-Strijbisfonds.
Prof. Teunissen has a collaboration contract with ADx Neurosciences, Quanterix, and Eli Lilly, performed contract research or received grants from AC-Immune, Axon Neurosciences, Biogen, Brainstorm Therapeutics, Celgene, EIP Pharma, Eisai, PeopleBio, Roche, Toyama, and Vivoryon.
