Sean Savitz, MD, The University of Texas Health Science Center, Houston, TX, talks on the various mechanisms of action of cell-based therapies currently under investigation for stroke and other neurological disorders, which he will discuss at the American Academy of Neurology virtual meeting 2021. Cellular therapies currently in clinical trials aid central nervous system (CNS) healing through altering inflammatory responses and enhancing the intrinsic repair capacity of the CNS. Investigations using IV administration of stem cells have demonstrated that these therapies can impact the brain without CNS penetration, through alteration of peripheral responses and the release of CNS-penetrant exosomes and nanovesicles. Prof. Savitz also discusses alternative delivery routes under assessment. This interview took place during the American Academy of Neurology (AAN) 2021 Annual Meeting.