Alberto Lleó, MD, PhD, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, expresses his confidence in the use of cerebrospinal fluid (CSF) biomarkers to diagnose Alzheimer’s disease (AD) compared to novel blood-based biomarkers, given the close proximity of CSF to the brain. Dr Lleó highlights the importance of an early confirmed diagnosis of AD due to the impact of the disease on the patient and their relatives. This interview took place at the Harvard European Alumni Training Network (HEAT-Net) 2021 congress.