Raúl Martínez-Fernandez, MD, PhD, and José Obeso, MD, PhD, University Hospital HM Puerta del Sur, Madrid, Spain, discuss the next steps on the evaluation of focused ultrasound (FUS) in Parkinson’s disease (PD) patients. The optimization of FUS regarding the size and shape of the lesion for each patient, bilateral treatment validation, and the early use of this technique are discussed. This interview took place during the American Academy of Neurology (AAN) 2021 Annual Meeting.