Recent years have seen exciting growth in the number of effective agents available for the preventive treatment of migraine. Dimos-Dimitrios Mitsikostas, MD, PhD, National & Kapodistrian University of Athens, Athens, Greece, addresses how these new treatments can be tailored into an individualized treatment plan now that there are numerous options available. Prof. Mitsikostas emphasizes the importance of consulting with patients on their individual needs and concerns in order to find the best-suited regimen for their lifestyle. This interview took place during the European Academy of Neurology 2021 congress.