VJVirtual | The role of HSCT in the treatment of relapsing-remitting and secondary progressive MS

Alice Mariottini, MD, University of Florence, Florence, Italy, discusses a study investigating long-term outcomes of hematopoietic stem cell transplantation (HSCT) in multiple sclerosis (MS) using an anti-thymocyte globulin (ATG)-based conditioning regimen. The study included 110 patients and reported a treatment-related mortality (TRM) of 0.9%. Viral reactivations requiring treatment occurred in 24% of patients. After a median follow-up of 5 years, the progression-free survival (PFS) and survival free from clinical or radiological activity were 69% and 68%, respectively. At 10 years, PFS was 100% in relapsing-remitting patients but only 27% in secondary progressive patients, highlighting the effectiveness of HSCT in relapsing-remitting MS and the need for further research to improve outcomes in secondary progressive MS. This interview took place at the 50th Annual Meeting of the EBMT in Glasgow, Scotland.

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