AAN 2024 | Defining distinct cognitive phenotypes in multiple sclerosis

Damiano Mistri, Neuropsychologist, PhD student, IRCCS San Raffaele Scientific Institute, Milan, Italy, discusses cognitive deficits in multiple sclerosis (MS) patients and his work on defining cognitive phenotypes. Up to 65% of MS patients experience deficits in at least one cognitive domain. Previous studies of patterns of cognitive deficits identified several phenotypes based on the number of impaired domains, but did not consider the severity of these impairments. Mr Mistri wanted to examine both the number of domains affected and severity of cognitive impairment in a cohort of MS patients, applying impairment criteria to memory, attention, and executive function performance. In a cohort of 243 patients with MS, five cognitive phenotypes were identified, each with distinct clinical, demographic, and structural MRI features. Further studies with longitudinal data will help to uncover how to these cognitive phenotypes could be used to tailor treatment and rehabilitation strategies for patients with MS. This interview took place at the American Academy of Neurology (AAN) Annual Meeting 2024 in Denver, CO.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.