Xavier Montalban, MD, PhD, BA, Vall d’Hebron University Hospital, Barcelona, Spain, comments on unmet needs in the field of multiple sclerosis (MS), including neurodegeneration and progressive MS. Prof. Montalban highlights over 100 trials investigating the latest therapies for MS that are currently being conducted as well as novel targets and molecules being developed. This interview took place at the American Academy of Neurology 2022 Congress in Seattle, WA.