Claudio Bassetti, MD, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland, shares an overview of updates on REM sleep behavior disorder (RBD) in Parkinson’s Disease (PD) discussed at the 2021 International Congress of Parkinson’s Disease and Movement Disorders. Topics discussed included diagnosing idiopathic RBD, predicting disease progression, and new frontiers in our understanding of the neurobiology of RBD and its association with synucleinopathies. This interview took place during the 2021 International Congress of Parkinson’s Disease and Movement Disorders.