Janu Thuraiaiyah, MD, PhD, Danish Headache Center, University of Copenhagen, Glostrup, Denmark, discusses the possible involvement of adenosine signaling in headache and migraine pathophysiology. Various studies have shown that the intravenous administration of adenosine can initiate headaches. Interestingly, the adenosine receptor antagonist, caffeine, has a dual effect and can trigger and relieve migraine attacks. To better understand the role of adenosine in migraine pathophysiology, further studies focusing on the subtypes of adenosine receptors are needed. This interview took place at the 16th European Headache Congress (EHC) in Vienna, Austria.
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