MDS 2020 | The gut-brain axis hypothesis in Parkinson’s disease pathology

Malú Tansey, PhD, University of Florida, Gainesville, FL, discusses the gut-brain axis hypothesis that suggests ɑ-synuclein aggregates in the periphery before the central nervous system. This hypothesis is consistent with reported gastrointestinal symptoms experienced in Parkinson’s disease before the onset of motor symptoms. Those with irritable bowel syndrome (IBS) or gut infections could be at a higher risk of Parkinson’s disease. Dr Tansey suggests that, although the hypothesis is promising, further research in animal models and humans is necessary. This interview was recorded during an online conference call with The Video Journal of Neurology (VJNeurology).