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CONy 2021 | Differential early subcortical involvement in genetic FTD

Previous studies have shown presymptomatic cortical atrophy in genetic frontotemporal dementia (FTD); however, not much is known about the involvement of subcortical regions. Martina Bocchetta, PhD, University College London, London, UK, gives an overview of a study examining the specific pattern of subcortical changes across the different disease stages of genetic FTD using data from the Genetic FTD Initiative (GENFI) cohort. Results showed a differential pattern of subcortical changes across severity stages in C9orf72, MAPT, and GRN mutation carriers, suggesting that subcortical brain volumes may be used as markers of neurodegeneration before the onset of prodromal symptoms. This interview was conducted during the virtual 2021 World Congress on Controversies in Neurology (CONy).