EAN 2022 | The role of oxidative stress in MS lesions

Hans Lassmann, MD, Medical University of Vienna, Vienna, Austria, discusses the role of oxidative stress in multiple sclerosis (MS). Oxidative stress driven by the inflammatory process has been identified as one of the main mechanisms of tissue injury in MS. Activated microglial cells produce enzymes that are involved in the formation of oxygen radicals that either damage the tissue directly or induce mitochondrial damage – leading to functional deficits and demyelination. Therefore, therapies that interfere with the oxidative stress pathway could be promising neuroprotective therapies. This interview took place at the 2022 Congress of the European Academy of Neurology (EAN) in Vienna, Austria.