Jiwon Oh, MD, PhD, St. Michael’s Hospital, University of Toronto, Toronto, Canada, highlights novel imaging biomarkers for multiple sclerosis (MS) as a major talking point at the ACTRIMS Forum 2022. Evidence is mounting in support of the relevance of paramagnetic rim lesions (PRLs) as valuable biomarkers in MS. It is believed that PRLs will have a role in differential diagnosis as well as prognostication. This interview took place at the ACTRIMS Forum 2022 in West Palm Beach, Florida.