Thomas Meinel, MD, Bern University Hospital, and University of Bern, Bern, Switzerland, talks on future research directions in covert brain infarctions (CBI). Currently, well-established strategies for manifest stroke, such as antithrombotic medication, lipid-lowering therapy as well as diagnostic studies such as rhythm monitoring, are unclear in CBI as an incidental finding. Hence, prospective studies evaluating if a diagnostic work-up in those patients is justified and if the benefits of those preventive strategies apply to patients with CBI are essential. This interview took place during the European Academy of Neurology 2021 congress.