Michel Torbey, MD, MPH, FAAN, University of New Mexico School of Medicine, Albuquerque, NM, discusses an assessment of the real-world clinical outcomes and resource use of patients with large hemispheric infarction (LHI). Over 11,000 patients with LHI were included in the retrospective cohort study, categorized as LHI with or without subsequent cerebral edema, and compared for 67,000 patients with other ischemic strokes. Analyses showed that LHI was associated with longer hospital stays, higher facility charges, and higher odds of death compared to the other ischemic strokes cohort. This increase in clinical management and resource burden was exacerbated by the occurrence of edema. This interview took place during the American Academy of Neurology (AAN) 2021 Annual Meeting.