Early diagnosis of patients with Parkinson’s disease is essential for the effectiveness of therapeutics. Tiago Outeiro, PhD, University Medical Center Göttingen, Göttingen, Germany, discusses core areas of research concerning the diagnosis of Parkinson’s disease. Core areas of research include non-motor symptoms, which occur before motor symptoms in Parkinson’s disease, biomarkers, e.g., in the cerebrospinal fluid (CSF), and imaging to observe the pathology. Technological innovations, such as wearables, are also being harnessed to detect subtle changes in patients before the onset of major symptoms. This interview took place during the European Academy of Neurology 2021 congress.