Richard Pither, PhD, Cytox Ltd, Oxford, UK, discusses the future role of genetics in the diagnosis and clinical management of Alzheimer’s disease. Dr Pither argues that genetics already play an important role, which is likely to expand in the future. Advances in the field have led to an improved understanding of the genetic underpinning of the common late-onset form of Alzheimer’s disease. Therefore, the current debate is not whether genetics should be used but rather how to use them in the management of Alzheimer’s disease and drug development. This interview was conducted during the virtual 2021 World Congress on Controversies in Neurology (CONy) meeting.