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ECTRIMS 2021 | Validating a 3D synthetic MRI method for myelin measurement

Quantitative assessment of myelination is an important biomarker to monitor patients with multiple sclerosis (MS) and evaluate treatment responses. Russell Ouellette, PhD, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden, shares an overview of his ongoing work aiming to validate a 3D synthetic MRI method for myelin imaging. Myelin measurement using quantitative synthetic MRI is fast and can create any contrast-weighted image that is clinically useful via simultaneous quantification of T1 and T2 relaxation times, and proton density. Current 2D methods have limitations in their ability to capture subtle myelination changes. Dr Ouellette and his group are investigating the feasibility and added value of using a 3D method for myelin detection. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) congress 2021.