Costantino Iadecola, MD, Cornell University, New York, NY, shares insights into Alzheimer’s disease (AD)-associated factors outside of the brain. While the impact of pathological changes inside the brain is well recognized in AD, hormonal, neuroimmune and systemic vascular influences are also critical players. Dr Iadecola talks on how these systems can lead to cerebral dysfunction, drawing attention to why their contributions should be considered in preventative and therapeutic approaches in AD. This interview took place during the AD/PD™ 2021 conference.