Tanuja Chitnis, MD, FAAN, Brigham and Women’s Hospital, Boston, MA, discusses an investigation of SARS-CoV-2 infection in patients with pediatric multiple sclerosis (MS). A large cohort was assessed to look at infection prevalence, features, and risk factors. Dr Chitnis talks on the identification of B-cell therapy use as a risk factor for severe COVID-19 disease. This interview took place during the American Academy of Neurology (AAN) 2021 Annual Meeting.