Joaquim Ferreira, MD, PhD, Faculty of Medicine, University of Lisbon, Lisbon, Portugal, discusses his appraisal of previous Huntington’s disease trials and why it is important to learn from their mistakes. As we enter a new era for Huntington’s disease clinical trials it is imperative that the same mistakes are avoided to minimize the risk of failing and to increase efficiency. This interview was recorded during an online conference call with The Video Journal of Neurology (VJNeurology).