Brian Weinshenker, MD, Mayo Clinic, Rochester, MN, discusses the issues with the criteria to diagnose multiple sclerosis. Currently, the criteria are too liberal and can lead to the misdiagnosis of patients. This can have a major psychological impact on patients who are misdiagnosed. Therefore, there is a need for a new set of criteria for general use in the clinic. This interview took place during the Virtual World Congress on Controversies in Neurology (CONy) 2020.