Irene Litvan, MD, FAAN, FANA, University of California San Diego, La Jolla, CA, highlights recent developments that have improved the diagnosis of atypical parkinsonism. New insights into the pathophysiology of atypical parkinsonian disorders have led to the discovery of novel biomarkers that can aid in diagnosis. Additionally, a substantial focus on identifying prodromal symptoms may aid earlier diagnosis. Many therapeutic trials are targeted towards the preclinical phase of disease and thus, identifying these patients early could have a great impact on outcomes. This interview took place during the 2021 International Congress of Parkinson’s Disease and Movement Disorders.