Torbjörn Tomson, MD, PhD, The Karolinska Institute, Solna, Sweden, describes the biggest challenges in treating epilepsy. Despite the introduction of new anti-seizure medications, about one-third of patients with epilepsy remain uncontrolled and continue to have seizures. And although epilepsy treatments, including new therapies, have shown to be effective, they continue to only reduce the risk of seizures rather than curing epilepsy. Prof. Tomson highlights that the future of epilepsy treatment is personalized epilepsy management. This interview took place during the European Academy of Neurology 2021 congress.