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MDS 2021 | Neuroinflammation in PD pathology

Etienne Hirsch, PhD, Institut du Cerveau-ICM, Inserm, Sorbonne Université, Paris, France, gives an overview of the evidence that supports a role for neuroinflammation in the pathophysiology of Parkinson’s disease. Both epidemiological and genetic studies in humans support the involvement of neuroinflammation in PD. Additionally, studies in postmortem PD brains have described the presence of activated microglial cells and infiltrating lymphocytes in the substantia nigra. There have also been several studies that have demonstrated the importance of immune activation in animal models of PD. Neuroinflammation has become more of a focus in field in recent years and targeting inflammation may be a promising new neuroprotective strategy. This interview took place during the 2021 International Congress of Parkinson’s Disease and Movement Disorders.