Edward Wild, MA, MB BChir, FRCP, PhD, UCL Queen Square Institute of Neurology, London, UK, discusses how somatic instability can cause the number of triplets in the Huntington gene to increase. Genome-wide association studies (GWAS) indicate that somatic instability is common and linked to DNA repair proteins. Therefore, DNA repair genes are potential therapeutic targets that could delay or prevent disease progression. Treatment targeting DNA repair genes could also benefit other neurodegenerative disorders. This interview was recorded during an online conference call with The Video Journal of Neurology (VJNeurology).