Robin Bessemer, MD, Western University, Ontario, Canada, comments on the challenges posed by a diagnosis of atypical parkinsonism. These neurodegenerative disorders, including supranuclear palsy (PSP) and multiple system atrophy (MSA), present with signs and symptoms like Parkinson’s disease, but have additional symptoms not typically seen in Parkinson’s and do not respond well to treatment with levodopa. Mobility problems, postural instability, autonomic features, bladder and bowel dysfunction, and speech issues are commonly seen. This complex symptom burden and accelerated disease course can make atypical parkinsonism challenging to manage. This interview took place at the American Academy of Neurology 2022 Congress in Seattle, WA.